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Eminent Speaker
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Haolin Zhang

Doctor

Beijing University of Technology

Biography

Haolin Zhang has expertise in cellular and molecular mechanisms of neurological diseases.His study revealed the early pathogenesis of Alzheimer's disease (AD) from the perspective of the imbalance of histone acetylation regulatory enzyme levels. He has proved that Tip60 protects against amyloid-β-induced transcriptomic alterations via different modes of action in early versus late stages of neurodegeneration. Further, Tip60-mediated abnormal epigenetic regulation of gene expression not only exists in AD but also in several other common neurodegenerative diseases: Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). His research also explored the cellular and molecular mechanisms of opioid addiction from the perspective of the abnormal changes in the developmental plasticity of adult brain neural stem cells. He has proved that the involvement of adult dentate gyrus neurogenesis in opioid addiction memory requires activation of the mu-opioid receptor (MOR)-CREB-miR-132 signaling pathway.

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