Hamad Bin Khalifa University
Ehsan Pourkarimi did his undergraduate study at ELTE University in Budapest, Hungary. After receiving a Cancer Research UK fellowship, he moved to the United Kingdom. He joined the Lab of Prof. Anton Gartner in the Wellcome Trust Center for Gene Regulation and Expression at the University of Dundee. During his Ph.D., Dr. Pourkarimi characterized the key components of the core apoptosis machinery in C. elegans and challenged the well-accepted model of apoptosis induction. Focused on chromatin biology, his post-doctoral research delved into the effect of chromatin modifiers in cellular response during acute stress conditions.
Using the SILAC-based proteomics approach, Dr. Pourkarimi demonstrated the significance of Histone H3.3 variants in aging and during acute starvation. As a Research Associate in the Lab of Dr. Iestyn Whitehouse at Memorial Sloan Kettering Cancer Center in New York City, Dr. Pourkarimi studied DNA replication. Using C. elegans embryos, he mapped DNA replication origins, creating the first comprehensive map of DNA replication from a multicellular organism.
In 2020 he moved to Qatar as principal investigator and assistant professor in Genomics and Precision Medicine (GPM) and established his research lab in Qatar. His Lab uses cutting-edge technology such as epigenome editing to tackle the fundamental question in chromatin biology, from DNA damage response to understanding the mechanism of epigenetic memory. He also uses a model system to understand the molecular pathology of cancer-causing mutations. His lab has recently identified the role of aminoacyl-tRNA synthetase (WARS1) in genome integrity and cancer.