Telomers are protective caps at the edges of chromosomes that play an important role in maintaining genetic stability. With all cell division, telomeres gradually become shorter and ultimately too short to protect DNA leads to aging or aging of the cells. This shortening process was an important marker of biological aging and was associated with age-related diseases such as cancer, cardiovascular disorders and neurodegeneration. Telomerase, an enzyme that can expand telomeres, is active in certain cell types and focused on senescence and regenerative medicine studies. Understanding telomere biology provides valuable insight into the aging process and potential strategies to promote healthy aging and durability.