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Senescence & Aging

Senescence refers to the biological process of cellular aging characterized by irreversible growth arrest and altered cellular function. It plays a dual role in aging: as a mechanism to suppress cancer by halting proliferation of damaged cells and as a contributor to tissue deterioration over time. Senescent cells accumulate with age and secrete inflammatory molecules, known as the senescence-associated secretory phenotype (SASP), which can promote tissue dysfunction and chronic inflammation. Research explores targeting senescent cells with senolytic therapies to remove or mitigate their harmful effects and potentially extend health span. Understanding senescence's role in aging offers insights into age-related diseases and strategies to promote healthier aging by addressing cellular senescence and its consequences.

  • Cellular Senescence
  • Biological Aging
  • Aging Mechanisms
  • Senescence Pathways
  • Age-related Cellular Changes
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