Mechanisms of Aging

Aging is a complex biological process driven by changes that occur at the molecular, cellular and organ levels. At the molecular level, it includes protein homostasis of aging DNA damage, reduced telomeres, oxidative stress, and disorders. At the cellular level, this includes cell senescence, reduced regenerative ability, and mitochondrial dysfunction. These changes lead to changes in signal paths and reduced cell functions. At the organ level, aging manifests as a gradual decline in tissue structure and function affecting systems such as the cardiovascular, nerve, and immune system. Understanding these interconnected mechanisms is essential for developing strategies to promote healthy aging and prevent age-related diseases.

  • Loss of Cell–Cell Communication in Aging
  • Genomic Instability and DNA Damage Accumulation
  • Proteostasis Decline and Protein Aggregation
  • Altered Intercellular Signaling and Hormonal Dysregulation
  • Musculoskeletal Aging: Bone and Muscle Interactions
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