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Immune Aging and Inflammaging

Immune Aging and Inflammaging

Immune rescue or immune rescue refers to the gradually decreasing of the immune system with age, leading to an infection, slow cure, and a weak ability to respond to vaccines. An important feature of immunity is inflammation. This is a chronic, low-grade inflammation that develops over time without obvious infection. This persistent inflammation contributes to the progression of many age-related diseases, including cardiovascular disease, diabetes, neurodegeneration, and cancer. Understanding the immune system and inflammation is important for developing strategies to strengthen immune function, reduce chronic inflammation, and promote healthier aging.

  • Immunosenescence: Mechanisms and Markers
  • Inflammaging and Age-Associated Diseases
  • B-cell Aging and Autoimmunity
  • Biomarkers of Inflammaging
  • Myeloid Cell Reprogramming in Aging
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Geriatrics and Medicine

Geriatrics and Medicine

Geriatrics is a medicine focused on health care for the elderly, aiming to promote healthy aging and treat age-related illnesses. As age increases, they are often exposed to several chronic diseases, increasing functional decline and susceptibility to disease. Geriatrics pursues a holistic approach that relates not only to medical issues but also to the psychological, social and functional aspects of aging. It emphasizes personalized care, prevention and maintaining independence to improve the quality of life of older adults.

  • Geriatric Rehabilitation and Healthy Aging Interventions
  • Geriatric Oncology: Cancer Screening and Treatment in Older Adults
  • Cardiovascular Disease Management in the Elderly
  • Multimorbidity and Polypharmacy in Aging Populations
  • Geriatric Pain Management and Non-Opioid Therapies

 

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Epigenetics and Gene Regulation in Aging

Epigenetics and Gene Regulation in Aging

Epigenetics refers to changes in genetic activity that do not contain changes in DNA sequences but are influenced by environmental and lifestyle factors. With increasing age, these epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling disrupt normal gene regulation, contribute to the development of cellular age, and can lead to disease. Epigenetic watches, a tool for measuring biological age based on DNA methylation patterns, have become an important marker for aging studies. Understanding how epigenetic mechanisms regulate gene expression provides valuable insight into the aging process and opens up new opportunities for interventions that may slow aging and prolong health spans.

  • DNA Methylation and Epigenetic Clocks
  • Non-coding RNAs in Aging Regulation
  • Epigenetic Regulation of Stem Cell Aging
  • CRISPR and Epigenome Editing for Aging Modulation
  • Epigenetic Biomarkers for Aging and Longevity
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Anti-Aging Strategies and Drug Development

Anti-Aging Strategies and Drug Development

The aim of anti-aging strategies and drug development is to slow or reverse the biological processes associated with aging, expanding the healthcare system and reducing the risk of age-related diseases. These approaches include lifestyle interventions such as calorie restriction, regular movement and reduction of stress, and the use of dietary supplements and pharmacologically active ingredients. In recent years, scientific advances in the development of promising drugs have led to aging pathways. This helps to slow cell aging and improve durability, such as aging, MTOR inhibitors, and NAD+ boosters. Ongoing research continues to investigate safe and effective treatments to promote healthy aging and improve the quality of life in later years.

  • Senolytics and Senomorphics: Clearing or Calming Senescent Cells
  • AI-Driven Drug Discovery for Longevity
  • Gene Therapy and RNA-Based Longevity Interventions
  • Drug Repurposing for Anti-Aging: From Diabetes to Geroprotection
  • Lipidomics and Anti-Aging Lipid Modulation
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Regenerative Medicine, Stem Cells and Aging

Regenerative Medicine, Stem Cells and Aging

Regenerative medicine is an innovative field focused on repairing or regenerating damaged tissues and organs, especially those affected by aging. Stem cells are vital to this process because they can transform into different cell types and aid in tissue renewal. As aging slows down the body’s natural healing abilities, regenerative therapies using stem cells offer potential to treat age-related diseases, restore function, and promote healthier aging.

  • Cellular Rejuvenation and Senescence Reversal
  • Exosomes and Extracellular Vesicles in Regeneration
  • Neural Regeneration and Brain Aging
  • Stem Cell Exhaustion and Aging Mechanisms
  • Mitochondrial Therapy
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Healthy Aging and Longevity

Healthy Aging and Longevity

Healthy aging and durability include more than long than long. They focus on better life with vitality, independence and good life in old age. As we grow older, it becomes more and more important to maintain our physical strength, mental acuity and emotional wells. Important factors that contribute to healthy aging are nutritious nutrition, regular movements, mental stimulation, high quality sleep, strong social connections, and daily medical examinations. Avoiding harmful habits such as smoking and excessive alcohol consumption also plays an important role. Genetics affects lifespan, but lifestyle and the environment have a big impact on the way we age. Promoting healthy aging not only prevents or delays age-related illnesses, but also helps to improve resilience, mobility and general life satisfaction.

  • Hormonal Balance and Endocrine Aging
  • Geroscience: Targeting the Biology of Aging
  • Hallmarks of Healthy Aging
  • Digital Health and Longevity Tech
  • Sleep and Circadian Health in Aging
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Cognitive Health and Neurodegenerative Disorders

Cognitive Health and Neurodegenerative Disorders

Cognitive health encompasses a range of mental abilities that enable us to process information, learn, remember, and communicate effectively. Neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (BVFTD) reflect the spectrum of cognitive impairment combined with cognitive decline. Traditional diagnostic approaches often overlook the general landscape of these obstacles.

  • Cognitive Impairment in Parkinson’s, ALS, and Huntington’s
  • Neuroplasticity and Cognitive Recovery
  • Cognitive Resilience and Brain Reserve
  • Precision Neurology and Genetic Risk Profiling
  • Long COVID and Post-Viral Cognitive Dysfunction
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Sarcopenia, Malnutrition and Therapy

Sarcopenia, Malnutrition and Therapy

Sarcopenia is a progressive loss of muscle mass and strength that occurs during aging, often leading to an increased risk of maneuverability, frailty, and reduction. It is closely linked to malnutrition as it is insufficient absorption of proteins, calories and essential nutrients, which can promote muscle loss. Elderly people are particularly vulnerable due to factors such as reduced appetite, illness, and social isolation. Effective treatments for sarcopenia include nutritional support, particularly protein and vitamin D supplementation. Early intervention is essential to maintain muscle function, improve physical performance, and maintain independence for ageing people.

  • Mechanisms and Molecular Pathways of Sarcopenia
  • Sarcopenic Obesity: Dual Burden of Fat and Muscle Loss
  • Appetite Regulation and Anorexia of Aging
  • Early Detection and Diagnostic Biomarkers for Sarcopenia
  • Sarcopenia drug development
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Cancer, Aging, and Metabolism

Cancer, Aging, and Metabolism

Cancer, aging, and metabolism are closely linked biological processes. With age, the body's ability to repair damaged cells decreases, increasing the likelihood of genetic mutations that can lead to cancer. Aging is linked to metabolic changes like decreased energy efficiency and increased oxidative stress, which can contribute to tumor development and overall cellular damage. Cancer cells take advantage of these altered metabolic pathways to fuel their unchecked growth. As a result, metabolism is an important focus in understanding cancer progression and the aging process. These explanations of connections open the door to innovative treatments aimed at cancer and age-related diseases.

  • Autophagy and Tumor Survival
  • Neuroendocrine Regulation of Cancer Risk During Aging
  • Geroscience-Guided Cancer Therapies
  • Nutrient-Sensing Pathways (mTOR, AMPK, SIRT) in Cancer and Aging
  • DNA Damage, Repair Mechanisms, and Cancer in Aging Tissues
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Mechanisms of Aging

Mechanisms of Aging

Aging is a complex biological process driven by changes that occur at the molecular, cellular and organ levels. At the molecular level, it includes protein homostasis of aging DNA damage, reduced telomeres, oxidative stress, and disorders. At the cellular level, this includes cell senescence, reduced regenerative ability, and mitochondrial dysfunction. These changes lead to changes in signal paths and reduced cell functions. At the organ level, aging manifests as a gradual decline in tissue structure and function affecting systems such as the cardiovascular, nerve, and immune system. Understanding these interconnected mechanisms is essential for developing strategies to promote healthy aging and prevent age-related diseases.

  • Loss of Cell–Cell Communication in Aging
  • Genomic Instability and DNA Damage Accumulation
  • Proteostasis Decline and Protein Aggregation
  • Altered Intercellular Signaling and Hormonal Dysregulation
  • Musculoskeletal Aging: Bone and Muscle Interactions
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Renal Aging

Renal Aging

The age of the kidney depends on the gradual decrease in kidney structure and function that develops with age. This procedure includes a decrease in the number of functional nephrons, a decrease in glomerular filtration rate (GFR), and a decrease in the ability to concentrate urine and regulate electrolyte balance. Structural changes such as glomerulosclerosis, interstitial fibrosis, and arteriosclerosis are also common. These changes are part of normal aging, but can increase the risk of chronic kidney disease (CKD), especially in combination with diseases such as hypertension and diabetes. Understanding the age of the kidneys is important for treating kidney health in older people and is to prevent functional declines.

  • Age-Related Decline in Glomerular Filtration Rate (GFR)
  • Drug Dosing and Nephrotoxicity in Aged Kidneys
  • Biomarkers of Renal Aging
  • Dialysis and Kidney Replacement Therapy in Older Adults
  • Renovascular Aging and Endothelial Dysfunction
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Biomarkers and Diagnostics in Aging

Biomarkers and Diagnostics in Aging

Biomarkers in aging are measurable indicators that reflect biological age and physiological processes underlying aging, not just chronologically. This includes markers of molecules, cells, and function, such as telomer length, inflammatory markers, epigenetic changes, and metabolic profiles. Reliable biomarkers can help in early detection of age-related diseases, monitoring the efficacy of anti-agent therapy, and assessing the general health of individuals. Advances in diagnostic equipment and technology enable accurate and personalized approaches to replace alternative research and care, supporting efforts to expand health coverage and prevent age-related declines.

  • Metabolomic and Lipidomic Biomarkers of Aging
  • Proteomic Profiling in Age-related Conditions
  • Cardiovascular Aging Biomarkers
  • Skin and Hair Biomarkers of Aging
  • Liquid Biopsy and Circulating Biomarkers
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Systemic Aging

Systemic Aging

Systemic aging refers to the progressive and coordinated reduction of several organ systems over time driven by complex biological, molecular and environmental factors. In contrast to aging of a single tissue or organ, systemic aging involves extensive changes in the body's unique, metabolic, cardiovascular, neurological and musculoskeletal systems. Understanding systematic aging is to identify previous decline markers and develop a holistic approach to promoting healthy age, prevent chronic diseases and improve overall life and healthy pot.

  • Cellular senescence
  • mitochondrial dysfunction
  • Inflammaging
  • DNA damage & repair
  • Liver Aging and Detoxification Decline
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Telomere Biology

Telomere Biology

Telomers are protective caps at the edges of chromosomes that play an important role in maintaining genetic stability. With all cell division, telomeres gradually become shorter and ultimately too short to protect DNA leads to aging or aging of the cells. This shortening process was an important marker of biological aging and was associated with age-related diseases such as cancer, cardiovascular disorders and neurodegeneration. Telomerase, an enzyme that can expand telomeres, is active in certain cell types and focused on senescence and regenerative medicine studies. Understanding telomere biology provides valuable insight into the aging process and potential strategies to promote healthy aging and durability.

  • Telomere Structure and Function in Cellular Aging
  • Telomere Shortening and Age-Related Diseases
  • Epigenetic Regulation of Telomere Dynamics
  • Telomere Dysfunction and DNA Damage Response (DDR) Activation
  • Telomeres in Reproductive Aging
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Rheumatology

Rheumatology

Rheumatism is a medical specialist focused on the diagnosis and treatment of rheumatic diseases that affect joints, muscles, bones and the immune system. These diseases include arthritis, lupus, gout, ankylosing spondylitis, and many autoimmune diseases. Rheumatic diseases often cause pain, inflammation, stiffness and mobility, which have a major impact on quality of life. Because many of these diseases are chronic and more common with age, rheumatology plays a critical role in improving function through long-term care treatment, reduced symptoms, medication, physical therapy, and lifestyle modifications.

  • Inflammatory Arthritis in the Elderly
  • Osteoarthritis: From Degeneration to Regeneration
  • Osteoporosis and Fragility Fractures
  • Geriatric Rheumatologic Aging-Related Disorders & Syndromes
  • Crystal Arthropathies in Aging
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Nutrition and Diet in Geriatric Care

Nutrition and Diet in Geriatric Care

Nutrition and nutrition play an important role in geriatric care as older people often face challenges such as reduced appetite, difficulty chewing and swallowing, and nutrient deficiencies. A balanced diet rich in protein, fiber, vitamins and minerals is important for supporting immune function, maintaining muscle mass and preventing chronic diseases. Proper nutrition is also useful for treating conditions such as diabetes, hypertension, and osteoporosis. In geriatric care, individualized nutritional plans and regular nutritional assessments are important to help older people maintain optimal health, energy levels and quality of life.

  • Macronutrient Needs in Older Adults
  • Malnutrition and Cachexia in Older Adults
  • Dysphagia and Texture-Modified Diets
  • Gut Microbiome and Aging: Nutritional Modulation
  • Anti-Inflammatory and Longevity Diets
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Dementia and Alzheimers

Dementia and Alzheimers

Dementia refers to a set of signs that extensively intrude with a persons day by day functioning, in the main affecting memory, communication, judgment, and problem-fixing abilties. It isn't a unmarried disease, however alternatively a standard time period that encompasses numerous unique situations resulting from odd adjustments withinside the brain. While dementia turns into greater not unusualplace with age, it isn't taken into consideration a regular a part of aging. Early analysis and supportive interventions can assist control signs, sluggish progression, and enhance great of existence for each sufferers and caregivers.

  • Neuroinflammation and Alzheimer’s Disease
  • Blood-based and CSF biomarkers
  • Artificial Intelligence and Digital Health in Dementia
  • Gut-Brain Axis and Alzheimer's
  • Longevity Drugs and Dementia Prevention
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Theories Of Aging

Theories Of Aging

The theory of aging aims to explain the biological mechanisms behind the aging process. Programmed theories suggest that aging is a genetically regulated process involving hormonal changes such as biological clocks and telomere reduction theory and neuroendocrine theory. Damage-based theories suggest that aging from cumulative damage occurs over time, including free radical theory, mitochondrial dysfunction, and DNA damage theory. Each theory provides insight into various aspects of aging. Together, it helps scientists understand the complexity of the aging process and manage the development of interventions to promote healthy aging and durability.

  • Mitochondrial Theory of Aging
  • Disposable Soma Theory
  • Neuroendocrine Theory of Aging
  • Epigenetic Theory of Aging
  • Stem Cell Exhaustion Theory
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